Esteban Orellana Vinueza, Ph.D. | The Pew Charitable Trusts

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Title: Assistant Professor
Department: Molecular and Systems Biology
Institution: Geisel School of Medicine at Dartmouth
Address: 66 College St
Remsen 725
City, State, ZIP: Hanover, NH 03755
Phone: 603-646-5962
Email: [email protected]
Website: https://orellanalab.org
Research field: Molecular biology, biochemistry
Award year: 2019

Research

The Orellana Lab studies the causes and effects of transfer RNA (tRNA) dysregulation in human disease and uses this knowledge to develop diagnostics and tRNA-based therapeutics. For many years, the contribution of tRNAs to human disease has been overlooked. Accumulating evidence indicates that the dynamic nature of tRNA modifications and the composition of the tRNA pool can contribute to human diseases, including cancer. The primary focus is to understand tRNA biology using cell culture and mouse models. The Orellana Lab employs bioinformatic, genetic, molecular, biochemical, and cell biological approaches to probe how perturbation of tRNAs results in disease.

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