Judd C. Rice, Ph.D.

Research

The major goals of the Rice Lab are to discover and study the molecular pathways that establish the various histone codes and, subsequently, to elucidate their roles in human development and disease. It is clear that histone modifications define specific genomic regions (i.e. those that are transcriptionally active or inactive) and that the modifications play an essential role in all DNA-templated programs. It is also clear that histone modifications act in concert with many other nuclear factors (including the DNA, the enzymes that write the histone code and the specific regulatory proteins that read the code) to create these distinct genomic regions.