Heather W. Pinkett, Ph.D. | The Pew Charitable Trusts

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Título: Assistant Professor
Departamento: Department of Biochemistry, Molecular Biology
Institución: Northwestern University
Dirección: 2205 Tech Drive
Ciudad, Estado, Código postal: Evanston, IL 60208
Número de teléfono: (847) 467-4048
Correo electrónico: [email protected]
Sitio: http://groups.bmbcb.northwestern.edu/pinkett/Welcome.html
Campo de investigación: Biochemistry; Biophysics
Año del premio: 2010

Research

My lab is exploring the molecular basis for transport, a cellular process that is universally conserved.To date, 13 human diseases are linked to defective transporters, including the multidrug resistance (MDR) phenomenon. ATP Binding Cassette (ABC) transporter proteins are major agents of multidrug resistance (MDR) in bacteria and humans. These membrane proteins harvest the energy of ATP hydrolysis to transport a vast range of molecules across cell membranes and act to protect cells from cytotoxic and antimicrobial agents. In order to determine the mechanisms underlying transport and its regulation, my lab uses a combination of x-ray crystallography, biochemistry and biophysics.

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